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Antibody Screening with Common Light Chain Ab Library

About Us

Our vision is to become the leader in the field of genetically modified animal models，helping people understand the life science and improving quality of life around the world.

Innovative Ab Drugs Development from target validation to IND application

Services

genetic engineering genetic animals genetic engineering examples

Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

Customization of MIT Mouse Recombinant mAb

U-GEMM Repository

The U-GEMM Repository has more than 6000 Genetically Engineered Mice & Rat Models, including KO , Flox，Cre/Dre, gene humanized knockin, Immunodeficiency, reporter Knockin , genetic disease and other models. You can Search for Mouse & Rat Models by Name, Catalog Number or Keyword.

U-GEMMsモデルリソースライブラリには

U-GEMMsモデルリソースライブラリには、KOモデルライブラリ、CKOモデルライブラリ、Find Cre ツールボックスマウス、遺伝的ヒト化マウス、免疫不全モデル、レポーターツールボックスマウス、蛍光トレーサーツールボックスマウス、遺伝性疾患モデルなどの複数のモデルを含む6000以上のモデルがあり、多くの人気分野をカバーしており、実験周期を効果的に短縮します。

U-GEMMs 모델 리소스 라이브러리

U-GEMMs 모델 리소스 라이브러리는6000가지가 넘는 모델을 보유하고 있으며, KO 모델 라이브러리，CKO 모델 라이브러리，Find Cre 도구 마우스，유전자 인간화 마우스，면역 결핍 모델，리포터 유전자 도구 마우스，형광 추적 도구 마우스，유전 질환 모델 등 여러 모델들이 있습니다. 여러 인기 영역에서 효과적으로 실험주기를 단축시킵니다! 

In-depth Antibody Humanization