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Models

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Mice

Rag2/IL2rg-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210231
Validation Data：Presence

Exon 3 of Rag2 and exon 2 of IL2rg gene was deleted to generate Rag2 and IL2rg knockout mice.

Mice

R26-SA-BirA

Strain Name：B6;129S-Gt(ROSA)26Sortm1(SA-BirA-V5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00085
Validation Data：Presence

A SA-BirA-polyA expression cassette was knocked in mouse Rosa26 loci . Heterozygous knockin mice developed normally.

Mice

Scx-IRES-CreERT2

Strain Name：C57BL/6Smoc-Scxem(IRES-CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215092
Validation Data：Presence

IRES-CreERT2-Wpre-pA expression cassette was knocked into the Scx gene .

Mice

Lgr5-2A-Dre

Strain Name：C57BL/6Smoc-Lgr5em1(2A-Dre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215042
Validation Data：Presence

2A-Dre expression cassette was knocked into the Lgr5 gene.

Mice

Il1f10-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1f10em1(Luc-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00060
Validation Data：Absence

A Luciferase-2a-egfp-polyA cassette was inserted at ATG site of mouse Il1f10 gene.

Mice

R26-CAG-EGFP(2)

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-EGFP-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190089
Validation Data：Absence

These mice harbor a CAG-EGFP-WPRE-polyA cassette in the Rosa26 locus.1 generated by homologous recombination. While R26-CAG-EGFP(Stock No.NM-KI-190088) and R26-CAG-EGFP(3)(Stock No.NM-KI-190090) function similarly to R26-CAG-EGFP(2) mice,for more detailed information please contact our technical advisor.

Mice

Slc17a6-IRES-Cre

Strain Name：C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200087
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.

Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014
Validation Data：Absence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

hCD3EDG/hCD20(2)

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Ms4a1tm2 (hCD20) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220119
Validation Data：Absence

hCD3EDG(NM-HU-220120) mice were crossed with hCD20(2)(NM-HU-200114) mice to generate hCD3EDG/hCD20(2).

Mice

hIL5/hIL5R(2)

Strain Name：C57BL/6Smoc-Il5em3(hIL5)Il5raem2(hIL5RA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-220010
Validation Data：Presence

The endogenous mouse Il5 and Il5ra genes was replaced by human IL5 and IL5ra genes. While hIL5/hIL5R(Stock No.NM-HU-2000101) mice and hIL5/hIL5R(3)(Stock No.NM-HU-220011) function similarly to hIL5/hIL5R(2) mice, for more detailed information please contact our technical advisor.

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