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Tfb2m-KO

Strain Name：C57BL/6Smoc-Tfb2m^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190886

Exon 3 of Tfb2m gene was deleted to generate Tfb2m knockout mice.

Cdkn2a/Cdkn2b-KO(p15/p16/p19-KO)

Strain Name：C57BL/6Smoc-Cdkn2a^emCdkn2b^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-241617

The p15/p16/p19-KO mouse model was established by knocking out all genomic regions between exon1 of the p15 gene and exon1 of the p16 gene.

Ldoc1-KO

Strain Name：C57BL/6Smoc-Ldoc1^em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-252160

The exon 1 of Ldoc1 gene was deleted to generate Ldoc1 knockout mouse. This gene overlaps with the ENSMUSG00000124784(lncRNA) gene at the genomic locus and may impact the function of the overlapping gene.

Cdkn2a/Cdkn2b-Flox(p15/p16/p19-Flox)

Strain Name：C57BL/6Smoc-Cdkn2a/Cdkn2b^{em1(flox)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-235093

The p15/p16/p19-Flox mouse model was obtained by inserting a loxp site upstream of the Cdkn2b gene exon 1 and another loxP site downstream of the Cdkn2a(p16) gene exon 1. The flox region of these strains contains the entire genomic region between exon1 of the p15 gene and exon1 of the p16 gene.

Polrmt-KO

Strain Name：C57BL/6Smoc-Polrmt^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190856

Exon 3-11 of Polrmt gene was deleted to generate Polrmt knockout mice.

Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer

Model Organisms：斑马鱼 Product & Service：- Research field：Drug screening and drug mechanism

Anti-Cancer Synergy MCF7 xenograft model

Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy

Model Organisms：小鼠 Product & Service：- Research field：

How do I identify the genotypes of genetically-engineered mice?

genomic DNA PCR gel electrophoresis

Why are there no non-specific bands or no band at all during genotyping?

genotyping PCR amplification annealing temperature

Harnessing the Power of the Cre-loxP System: Benefits, Challenges, and Applications

This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.