Welcome to Advanced Search

Tfb2m-KO

Strain Name：C57BL/6Smoc-Tfb2m^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190886

Exon 3 of Tfb2m gene was deleted to generate Tfb2m knockout mice.

Cdkn2a/Cdkn2b-KO(p15/p16/p19-KO)

Strain Name：C57BL/6Smoc-Cdkn2a^emCdkn2b^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-241617

The p15/p16/p19-KO mouse model was established by knocking out all genomic regions between exon1 of the p15 gene and exon1 of the p16 gene.

Cdkn2a/Cdkn2b-Flox(p15/p16/p19-Flox)

Strain Name：C57BL/6Smoc-Cdkn2a/Cdkn2b^{em1(flox)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-235093

The p15/p16/p19-Flox mouse model was obtained by inserting a loxp site upstream of the Cdkn2b gene exon 1 and another loxP site downstream of the Cdkn2a(p16) gene exon 1. The flox region of these strains contains the entire genomic region between exon1 of the p15 gene and exon1 of the p16 gene.

Polrmt-KO

Strain Name：C57BL/6Smoc-Polrmt^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190856

Exon 3-11 of Polrmt gene was deleted to generate Polrmt knockout mice.

Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer

Model Organisms：斑马鱼 Product & Service：- Research field：Drug screening and drug mechanism

Anti-Cancer Synergy MCF7 xenograft model

How do I identify the genotypes of genetically-engineered mice?

genomic DNA PCR gel electrophoresis

Why are there no non-specific bands or no band at all during genotyping?

genotyping PCR amplification annealing temperature

Harnessing the Power of the Cre-loxP System: Benefits, Challenges, and Applications

This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.

How to Verify Your Cre-lox Model

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.