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Models

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Mice

Akt1-KO

Strain Name：C57BL/6Smoc-Akt1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190741

Exon 2 of Akt1 gene was deleted to generate Akt1 knockout mice.

Mice

Il1b-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-luc)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00001

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

Mice

HBV-Tg

Strain Name：B6.Cg-Tg(HBV)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00003

Full-length HBV genome (adrsubtype,C genotype) was used to establish the transgenic mice. HBsAg was positive in transgenic mice serum; no serum HBeAg anti-HBs, anti-HBe, or antiHBc was detected. No anti-HBs or anti-HBe was detected in the polyethylene gly.

Mice

Vip-IRES-Cre

Strain Name：C57BL/6Smoc-Vipem1(IRES-iCre-SV40-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200100

A IRES-iCre expression cassette was knocked into the Vip gene stop codon site. Vip encodes vasoactive intestinal polypeptide. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in cells expressing. This strain is useful for studying bronchiectasis, immunomodulatory and anti-inflammatory.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

Mice

Stradb-KO

Strain Name：C57BL/6Smoc-Stradbem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191113

Exon 4 of Stradb gene was deleted to generate Stradb knockout mice.

Mice

Stat5b-KO

Strain Name：C57BL/6Smoc-Stat5bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190882

Exon 4-5 of Stat5b gene was deleted to generate Stat5b knockout mice.

Mice

Sphk1-KO

Strain Name：C57BL/6Smoc-Sphk1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-191035

Sphk1-KO mice(Stock No.NM-KO-191035）carry a knockout allele derived from the targeted deletion of exon 4.

Mice

hAGT

Strain Name：C57BL/6Smoc-Agttm1(hAGT)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225082

The endogenous mouse Agt gene was replaced by human AGT gene.

Mice

Agt-KO

Strain Name：C57BL/6Smoc-Agtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190740

Exon 2-5 of Agt gene was deleted to generate Agt knockout mice.

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