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Advancing Cancer Therapy: Harnessing In Vivo Tumor Models for Breakthrough Drug Development

Cancer therapy advancements In vivo tumor models Preclinical cancer research Drug development in oncology Gene-modified cell lines Immuno-oncology Tumor modeling for drug discovery Cancer drug development Animal modeling services Cancer drug preclinical models

Join us for an insightful webinar exploring the critical role of in vivo tumor models in advancing cancer drug therapy. We will provide an overview of the diverse tumor models developed by our company, highlighting case studies demonstrating their effectiveness in preclinical cancer research. The session will delve into the comprehensive use of gene-modified cell lines and genetically modified spontaneous mouse models, showcasing their application in mimicking human cancer biology. We will conclude with a brief introduction to our company and our commitment to accelerating cancer drug development through innovative animal modeling services.

Disease Mouse Models (Non-genetically-engineered)

diseases mice diseases model non genetically modified organisms

Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Model Repository

model repository

Shanghai Model Organisms has established more than 18,000 genetically modified mouse models using three core technologies of gene editing. It has more than 10,000 proprietary genetically engineered mouse models that can be directly used for studies on gene functions, drug screening, and human diseases. At the same time, Shanghai Model Organisms has more than 30 fluorescent-labeled tumor cell lines, which can be used for in vitro experiments, studies on tumor bearing mice and other tumor researches.

Dysgenesis model

infertility diseases prss37 gene KO mice

Prss37 gene knockout infertility mouse model. SMOC has developed the Prss37 gene knockout mouse model (Prss37 KO, Model No.: NM -KO-00016) by ES cell targeting. It is a homozygous male infertility model.

Humanized Mice

NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.

Humanized Mice

NMG and NMG-B2m mice transplanted with human-derived PBMC are suitable for short-term in vivo tests requiring mature T cell function, including studies on HIV infection, immuno-oncology and GvHD.

Why We Need Humanized Mice?

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Gene Knockout

gene knockout gene knockout technology knockout mice

Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.