Therapeutic Target-Humanized Mice
Cre/Dre-Driver Mice
Immunodeficient NMG Mice
This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.
Bone metastasis cancer model Pain-related behavior assessment Cancer-induced bone pain Bone cancer pain models Mouse bone metastasis model Animal models in cancer research Cancer research services Bone metastasis in mice Pain management in cancer
We are excited to announce that GenoBioTX has launched a new service featuring mouse bone metastasis cancer models and pain-related behavior assessment, designed to support cancer research and pain management effectively.
sentinel mice BALB/c mice C57BL/6 mice
As a biotechnology company specializing in animal model R&D, rearing and breeding, as well as analysis and testing, GenoBioTX is dedicated to providing our clients with comprehensive, convenient and professional animal model services.
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Shanghai Model Organisms Center (SMOC) is dedicated to protecting your privacy and works hard to provide all users with a safe online environment.
immunotherapy immune checkpoint immune checkpoint genes
As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.
NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.
laboratory animal welfare
Shanghai Model Organisms Center (SMOC) has always placed significant emphasis on the welfare of laboratory animals and treats all laboratory animals with respect.
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