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Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Pathological Analysis

Pathological analysis H&E staining

Shanghai Model Organisms can analyze morphological and pathological changes in various animal tissues.

Gene overexpression

gene overexpression gene overexpression protocol gene overexpression techniques

Generate a mouse model in which an exogenous gene is introduced and overexpressed. An overexpression model can be used to investigate gene functions, promoter functions, or model the pathogenesis of human disease. Depending on the method to introduce foreign DNA, a random transgenes or targeted conditional overexpression model can be created.

Humanized Mice

NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.

Humanized Mice

NMG and NMG-B2m mice transplanted with human-derived PBMC are suitable for short-term in vivo tests requiring mature T cell function, including studies on HIV infection, immuno-oncology and GvHD.

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

In Vivo Efficacy Evaluation

Innovative Ab Drugs Development from target validation to IND application

Gene Knockout

gene knockout gene knockout technology knockout mice

Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.