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Nr1i3-KO(SD)

Strain Name：SD-Nr1i3^em1Smoc Strain State：Embryo cryopreservation | Cat. NO.：NR-KO-190008

Exon 2 of Nr1i3 gene was deleted to generate Nr1i3 knockout rat.

Abcg2-KO(SD)

Strain Name：SD-Abcg2^em1Smoc Strain State：Repository Live | Cat. NO.：NR-KO-190007

Exon 4-5 of Abcg2 gene was deleted to generate Abcg2 knockout rat.

Abcc2-KO(SD)

Strain Name：SD-Abcc2^em1Smoc Strain State：Embryo cryopreservation | Cat. NO.：NR-KO-200002

Exon 4-6 of Abcc2 gene was deleted to generate Abcc2 knockout rat.

ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells

Model Organisms：小鼠 Product & Service：Zfp91-floxed Research field：T cell

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

Model Organisms：Mouse Product & Service：Agk Research field：Immune system

Advanced paternal age increased metabolic risks in mice offspring

Model Organisms：小鼠 Product & Service：HFD Research field：Metabolism

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders

Model Organisms：小鼠 Product & Service：Uox Research field：kidney

尿酸氧化酶 uricase Uox 尿酸酶 高尿酸血症 hyperuricemia HUA

CKO mice developed by SMOC supported the identification of a novel lncRNA that regulates dendritic cell migration and the corresponding immune response

CKO mice lncRNA dendritic cell

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.