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hAPOL1-G2-Tg(FVB)

Strain Name：FVB-Tgtn(hAPOL1-G2)1Smoc
Strain State：Developing | Cat. NO.：NM-TG-252716

These transgenic mice harbor hAPOL1-G2 expression cassettes.

hAPOL1-G1-Tg(FVB)

Strain Name：FVB-Tgtn(hAPOL1-G1)1Smoc
Strain State：Developing | Cat. NO.：NM-TG-252620

These transgenic mice harbor hAPOL1-G1 expression cassettes.

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sor^{tm1(Gut-CYP3A4-IRES-tdTomato)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

rIns1-hGAST-IRES-tdTomato-Tg(FVB)

Strain Name：FVB-Tgtn(rIns1-hGAST-IRES-tdTomato)1Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-254223

These transgenic mice harbor rIns1-hGAST-IRES-tdTomato expression cassettes.

Rag2-KO/pMMTV-Erbb2*V664E-Tg(FVB)

Strain Name：FVB-Rag2^em1Tg(pMMTV-Erbb2*V664E)1^Smoc
Strain State：Developing | Cat. NO.：NM-XA-241615

The Rag2-KO(FVB)(NM-KO-233033) was crossed with pMMTV-Erbb2*V664E-Tg(FVB)(NM-TG-220194) to generate Rag2-KO/pMMTV-Erbb2*V664E-Tg(FVB) mice.

Uchl3-Flox/Myh6-Cre/Esr1-Tg(B6;FVB)

Strain Name：B6;FVB-Uchl3^em1(flox)Tg(Myh6-creER)Smoc
Strain State：Developing | Cat. NO.：NM-XA-260066

The Uchl3-Flox (NM-CKO-254199) was crossed with Myh6-Cre/Esr1-Tg(NMX)(NMX-TG-192029) to generate Uchl3-Flox/Myh6-Cre/Esr1-Tg(NMX) mice.

pTRE-Mir31-Tg

Strain Name：B6;FVB-Tg(pTRE-Mir31)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-TG-210230

These transgenic mice harbor pTRE-Mir31 expression cassettes.

Senp8-Flox/Myh6-Cre/Esr1-Tg

Strain Name：B6;FVB-Senp8^em1(flox)Tg(Myh6-creER)Smoc
Strain State：Developing | Cat. NO.：NM-XA-260056

The Senp8-Flox (NM-CKO-253678) was crossed with Myh6-Cre/Esr1-Tg(NMX)(NMX-TG-192029) to generate Senp8-Flox/Myh6-Cre/Esr1-Tg(NMX) mice.

Col1a1-tetO-EML4-ALK

Strain Name：C57BL/6Smoc-Col1a1^{tm1(TetO-EML4-ALK)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：DM-KI-251860

The human EML4-ALK gene was cloned into a TetO-EML4-ALK construct and microinjected into FVB zygotes, where it was inserted into the mouse Col1a1 locus. This strain was donated by the laboratory of Academician Liang Chen at Jinan University. Any published research papers or other forms of literature should cite: "Zhou Q, Yang T, Yu X, et al. Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. EMBO Mol Med. 2025;17(3):563-588. doi:10.1038/s44321-025-00200-y"

What is an inbred strain?

inbreeding coefficient inbreeding depression FVB