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Gene Knockout

gene knockout gene knockout technology knockout mice

Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Integrated Solutions

Super-trillion Innovative Antibody Drug Discovery Platform

Customization of Anti-drug Antibody

Nervous System

neuropsychiatric disorder models parkinson's disease models

The model of nerve injury induced by surgery or drugs can be used to study the mechanism of nerve injury and to evaluate drug efficacy.

Disease Mouse Models (Non-genetically-engineered)

diseases mice diseases model non genetically modified organisms

Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Model Repository

model repository

Shanghai Model Organisms has established more than 18,000 genetically modified mouse models using three core technologies of gene editing. It has more than 10,000 proprietary genetically engineered mouse models that can be directly used for studies on gene functions, drug screening, and human diseases. At the same time, Shanghai Model Organisms has more than 30 fluorescent-labeled tumor cell lines, which can be used for in vitro experiments, studies on tumor bearing mice and other tumor researches.

Immunology and Inflammation

Inflammatory mouse

Shanghai Model Organisms provides a variety of mouse models of inflammation including exarteritis, chemotherapy-induced intestinal inflammation and inflammatory bowel disease. These models can be applied in researches on the mechanism of inflammation, evaluation of drug efficacy, and others.

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

Customization of MIT Mouse Recombinant mAb