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In Vivo Efficacy Evaluation

Antibody Affinity Maturation

Our Credentials

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

Gene Expression/Protein Analysis

protein expression analysis Gene expression analysis

Shanghai Model Organisms provides high-quality gene and protein expression analysis services, including RT-PCR, real time PCR, and Western blot, with accurate experimental results that can be used for publication.

Endocrinology and Metabolism

Diabetic mouse model type 2 diabetes mouse model

Long-term feeding of high-fat diets can cause obesity and increased fasting blood glucose in mice along with fat accumulation and insulin resistance in the body to mimic human type II diabetes.

Excision and Regeneration of Tissue

liver regeneration subtotal gastrectomy

A mouse tissue regeneration model can be established by an operation of partial tissue excision. Such models can be used to study the changes in morphology, serology and metabolism during tissue regeneration, and hence lay the experimental foundation for studying the mechanisms regulating tissue regeneration.

Development of Purification Process

Hemophilia Model

f8 gene f9 gene hemophilia research

The F8 and F9 gene knockout mice were generated by Shanghai Model Organisms Center (SMOC)

Dysgenesis model

infertility diseases prss37 gene KO mice

Prss37 gene knockout infertility mouse model. SMOC has developed the Prss37 gene knockout mouse model (Prss37 KO, Model No.: NM -KO-00016) by ES cell targeting. It is a homozygous male infertility model.