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SMOC Received OLAW (Office of Laboratory Animal Welfare) Approval for Animal Welfare Assurance

Shanghai Model Organisms Center Inc.(SMOC) received the approval of Animal Welfare Assurance from the Office of Laboratory Animal Welfare (OLAW) of the U.S. National Institutes of Health (NIH) for its animal facility on January 25, 2021.

News Update: GenoBioTX and Crown Bioscience Sign Global Cooperation Agreement

Research on Diseases

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Shanghai Model Organisms provides a professional R&D platform for genetically-engineered mouse, zebrafish and nematode models, a service platform for phenotyping, and a rich repository of disease mouse models to support your studies on disease genetics, pathogenesis, drug treatments, and more.

Services

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Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

Applications of Animal Models

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The model animal has played an important role in the history of life sciences and medicine, with a wide range of application in biology, medicine, molecular biology, molecular genetics, immunology and other fields.

Popular Model Organisms

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Inflammation Models

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Inflammation is a common yet important pathological process. Any factor that may cause tissue damage can lead to inflammation. Anomal inflammatory response may result in chronic inflammation, autoimmune diseases and even cancer. The regulation of inflammation-related genes is an important topic in the study of the development of inflammation.

Disease Mouse Models (Non-genetically-engineered)

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Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Osteoporosis

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Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.