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Popular Model Organisms

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Type of genetic engineering

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Three types of genetic modification by the gene engineered technology: gene knockout. gene knock-in, gene overexpression.

Gene Knockout

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Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Cancer Model

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The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

Aging and Longevity Research

Humans have always been fascinated with the study of aging. Despite experiencing thousands of years of civilization, we have yet to clearly identify the mechanisms of aging. Either from the perspective of drug development or genetic research, the study of aging is undoubtedly a worthy cause.

U-GEMM Repository

The U-GEMM Repository has more than 6000 Genetically Engineered Mice & Rat Models, including KO , Flox，Cre/Dre, gene humanized knockin, Immunodeficiency, reporter Knockin , genetic disease and other models. You can Search for Mouse & Rat Models by Name, Catalog Number or Keyword.

Disease Mouse Models (Non-genetically-engineered)

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Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Brca1 CKO Mouse Model

Our own-developed Brca1 conditional knockout mice (Brca1-CKO) can be used to study breast cancer.

Syngeneic Models

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