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Study of Gene Functions

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P53 CKO Mouse Model

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Our own-developed mouse model of p53 conditional knockout (p53-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of p53 in specific tissues or cells. These mice can be used for tumorigenesis and tumor mechanistic studies.

Gene overexpression

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Generate a mouse model in which an exogenous gene is introduced and overexpressed. An overexpression model can be used to investigate gene functions, promoter functions, or model the pathogenesis of human disease. Depending on the method to introduce foreign DNA, a random transgenes or targeted conditional overexpression model can be created.

Milestones

Mouse Models Expedite the Elucidation of AD Pathogenesis

Immunology and Inflammation

Inflammatory mouse

Shanghai Model Organisms provides a variety of mouse models of inflammation including exarteritis, chemotherapy-induced intestinal inflammation and inflammatory bowel disease. These models can be applied in researches on the mechanism of inflammation, evaluation of drug efficacy, and others.

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

GEMM-Derived Allografts

SmocMab Fully-human Antibody Transgenic Mouse

In Vivo Efficacy Evaluation