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Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

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As a biotechnology company specializing in animal model R&D, rearing and breeding, as well as analysis and testing, GenoBioTX is dedicated to providing our clients with comprehensive, convenient and professional animal model services.

About Us

Our vision is to become the leader in the field of genetically modified animal models，helping people understand the life science and improving quality of life around the world.

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

Drug Screening

drug screening high throughput screening for drug discovery

With a comprehensive model organisms service platform that generates the mouse, zebrafish and C. elegans models, Shanghai Model Organisms enables high-throughput drug screening as well as the evaluation and research on drug efficacy, thus accelerating drug development and achieving greater accuracy in the prediction of in vivo interactions.

Breeding Services

We will delivery the specific genotype model product within specific period by natural breeding or assisted reproduction technology. The specified breeding technologies include natural breeding, assisted reproduction, SPF purification, etc.

Research on Diseases

genetics diseases studies diseases research diseases

Shanghai Model Organisms provides a professional R&D platform for genetically-engineered mouse, zebrafish and nematode models, a service platform for phenotyping, and a rich repository of disease mouse models to support your studies on disease genetics, pathogenesis, drug treatments, and more.

モデルマウスの繁殖

カスタマイズされた後のモデル、またはお客様の既有の遺伝子組み換え動物モデルは、自然繁殖または補助的生殖繁殖の方法によって、特定周期に、特定遺伝子型モデル製品として提供されます。具体的には、自然繁殖、補助的生殖繁殖、 SPF精製等が含まれます。

모델 번식

특정 유전자 조합 모델 상품을 자연 번식 혹은 보조 생식하여 특정 시기에 납품됩니다. 이미 고객님이 보유한 유전자 변형 동물 모델 또한 자연 번식 혹은 보조 생식 서비스를 제공합니다.구체적 번식 기술: 자연 번식, 보조 생식, SPF 정화 등.

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