In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Cdkl5em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2108806
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Strain Name：C57BL/6Smoc-Cdkn1aem2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200033
Disease Connection：urinary bladder cancer
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Strain Name：C57BL/6Smoc-Cdkn1bem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200032
Research Application：Cancer research
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Strain Name：C57BL/6Smoc-Cdkn2aem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-234392
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Strain Name：C57BL/6Smoc-Cdkn2aem3(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200015
Disease Connection：melanoma, alveolar rhabdomyosarcoma, skin melanoma, sarcoma, pancreatic ductal adenocarcinoma, pancreatic carcinoma
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Strain Name：C57BL/6Smoc-Cdkn2aem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200151
Disease Connection：melanoma, alveolar rhabdomyosarcoma, skin melanoma, sarcoma, pancreatic ductal adenocarcinoma, pancreatic carcinoma
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Strain Name：C57BL/6Smoc-Cdkn2a/Cdkn2bem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-235093
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Strain Name：C57BL/6Smoc-Cdkn2aipnlem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
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