In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：B6;129S-Esrratm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00039
Research Application：Metabolism，Metabolism of lipids and lipoproteins，Mitochondrial biogenesis
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Strain Name：C57BL/6Smoc-Esrrbem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253925
Disease Connection：dilated cardiomyopathy
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Strain Name：C57BL/6Smoc-Esx1em1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-260799
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