Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Tnfrsf13bem(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-230123
Mice
Strain Name:C57BL/6Smoc-Tnfrsf13cem(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-220634
Mice
Strain Name:C57BL/6Smoc-Tnfrsf14em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Tnfrsf19em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-233050
Mice
Strain Name:C57BL/6Smoc-Tnfrsf1aem1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-231253
Mice
Strain Name:C57BL/6Smoc-Tnfrsf1bem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-226063
Mice
Strain Name:C57BL/6Smoc-Tnfrsf21em(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-220203
Mice
Strain Name:C57BL/6Smoc-Tnfrsf22em1(flox)Smoc
Strain State:Developing | Cat. NO.:NM-CKO-260785
Mice
Strain Name:C57BL/6Smoc-Tnfrsf23em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Tnfrsf25em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2116228
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