In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6JSmo-Ppardtm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190068
Research Application：NASH(nonalcoholic steatohepatitis) research
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Strain Name：C57BL/6JSmo-Ppargtm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190071
Disease Connection：primary pulmonary hypertension, systemic lupus erythematosus
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Strain Name：C57BL/6JSmo-Ppargc1aem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-2100610
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Strain Name：C57BL/6JSmo-Ppatem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253933
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Strain Name：C57BL/6JSmo-Ppbpem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-232125
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Strain Name：C57BL/6JSmo-Ppdpfem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-234712
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