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Models

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Mice

hIL7R

Strain Name：C57BL/6JSmo-Il7rtm1(hIL7R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210027
Validation Data：Presence

The endogenous mice Il7r gene was completely or partially replaced by human IL7R gene via ESC targeting.

Mice

Lyz2-IRES-DTRGFP

Strain Name：C57BL/6JSmo-Lyz2em3(IRES-DTREGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190041
Validation Data：Presence

A IRES-DTREGFP expression cassette was knocked into the Lyz2 gene stop codon site.

Mice

hIL15-TgV1(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Tg(hIL2 SP-hIL15)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220133
Validation Data：Presence

These transgenic mice carry human IL15.

Mice

Atp4b-IRES-CreERT2(2)

Strain Name：C57BL/6JSmo-Atp4bem2(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210119
Validation Data：Presence

An IRES-CreERT2 expression cassette was knocked into the Atp4b gene stop codon site. Besides,An IRES-CreERT2-WPRE-pA expression cassette were knock into the Atp4b gene start codon site to generate Atp4b-IRES-CreERT2(Stock No. NM-KI-210118) mice. ATP4B could serve as a tumor suppressor in the tumorigenesis and progression. This strain is useful in studying the function of gastric parietal cells in gastric epithelial homeostasis. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cre-expressing cells after tamoxifen treatment.

Mice

hCTLA-4(BALB/c)

Strain Name：BALB/cJSmo-Ctla4tm1(hCTLA4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190078
Validation Data：Presence

Obtained by backcrossing of NM-HU-00014，hCTLA-4 mice.

Mice

hFCGR2B/h4-1BB(2)

Strain Name：C57BL/6JSmo-Fcgr2btm2(FCGR2B)Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210352
Validation Data：Presence

hFCGR2B(NM-HU-2000010) was crossed with h4-1BB (NM-HU-190077) to generate hFCGR2B/h4-1BB mice.

Mice

hPD-1/hSTING

Strain Name：C57BL/6JSmo-Tmem173tm1(hTMem173)Pdcd1tm1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000104

hPD-1(NM-HU-00015) was crossed with hSTING(NM-HU-190036) to generate hPD-1/hSTING.

Mice

Csf2rb2-2A-Cre

Strain Name：C57BL/6JSmo-Csf2rb2em1(2A-Cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210001
Validation Data：Presence

2A-Cre expression cassette was knocked into the Csf2rb2 gene. Csf2rb2 is also known as colony stimulating factor 2 receptor. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. The gene product has been involved in the modulation of memory.

Mice

hIL23A(BALB/c)

Strain Name：BALB/cJSmo-Il23atm3(hIL23A)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220013
Validation Data：Presence

The endogenous mouse Il23a gene was replaced by human IL23A gene.

Mice

hSERPINC1

Strain Name：C57BL/6JSmo-Serpinc1tm1(hSERPINC1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225075
Validation Data：Presence

The endogenous mouse Serpinc1 gene was replaced by human SERPINC1 gene.

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