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Models

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Mice

Scgb1a1-IRES-Cre

Strain Name：C57BL/6JSmo-Scgb1a1em1(IRES-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210120
Validation Data：Presence

IRES-Cre expression cassette was knocked into the Scgb1a1 gene.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA-4

Strain Name：C57BL/6JSmo-Fcgr2bem1Fcgr3em1Fcgr4em1Ctla4em1(hCTLA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220069

The Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA4 mouse model was obtained by deleting all sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hCTLA4(NM-HU-00014) mouse.

Mice

hCXCL13

Strain Name：C57BL/6JSmo-Cxcl13tm1(hCXCL13)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225079
Validation Data：Presence

The endogenous mouse Cxcl13 gene was replaced by human CXCL13 gene.

Mice

hIL21

Strain Name：C57BL/6JSmo-Il21tm1(hIL21)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200255
Validation Data：Presence

The endogenous mice Il21 gene was replaced by human IL21 gene.

Mice

Map2-2A-CreERT2

Strain Name：C57BL/6JSmo-Map2em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00037
Validation Data：Presence  |  Publications：1piece

Map2 is a marker of mature neurons. A 2A-CreERT2 cassette was inserted before the translational termination site of the Map2 locus.

Mice

Il16-Luc-2A-EGFP

Strain Name：C57BL/6JSmo-Il16em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00028

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il16.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6JSmo-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

Ctsk-2A-CreERT2

Strain Name：C57BL/6JSmo-Ctskem1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200067
Publications：1piece

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ctsk gene stop codon site.

Mice

Shh-CreERT2

Strain Name：C57BL/6JSmo-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145
Validation Data：Presence

A CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site.

Mice

Gli1-CreERT2

Strain Name：C57BL/6JSmo-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073
Validation Data：Presence

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

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