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Models

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Mice

hTIGIT/hPVR

Strain Name：C57BL/6Smoc-Tigitem1(hTIGIT)Pvrem1(hPVR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000091
Validation Data：Presence

These mice are obtained through breeding of hTIGIT(NM-HU-00053) and hPVR(NM-HU-190012) mice.

Mice

Smad4-Flox

Strain Name：C57BL/6Smoc-Smad4tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18011
Validation Data：Absence

These mice carry loxP sites flanking exon3-4 of Smad4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Smad4 gene.

Mice

hPD-1/hICOS(2)

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Icosem1(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000100
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hICOS(2)(NM-HU-190030) to generate hPD-1/hICOS(2).

Mice

Ctf1-KO

Strain Name：C57BL/6Smoc-Ctf1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190546
Validation Data：Absence

Exon 2 of Ctf1 gene was deleted to generate Ctf1 knockout mice.

Mice

Pdyn-IRES-Cre

Strain Name：C57BL/6Smoc-Pdynem1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200089
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.

Mice

Gpr12-KO

Strain Name：C57BL/6Smoc-Gpr12em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200978
Validation Data：Absence

Exon 2 of Gpr12 gene was deleted to generate Gpr12 knockout mice.

Mice

KPC(2)

Strain Name：C57BL/6Smoc-Trp53tm7(R270H-flox)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220014
Validation Data：Absence

Trp53-LSL-R270H, Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. While KPC mice function similarly to KPC(2) mice, for more detailed information please contact our technical advisor.

Mice

Slc6a4-Cre

Strain Name：C57BL/6Smoc-Slc6a4em1(iCre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200115
Validation Data：Presence

A iCre-pA expression cassette was knocked into the Slc6a4 gene start codon site. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. The gene product has been involved in the neurological disorders such as addiction and depression.

Mice

Taar1-KO

Strain Name：C57BL/6Smoc-Taar1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-2112327
Validation Data：Absence

Exon 1 of Taar1 gene was deleted to generate Taar1 knockout mice.

Mice

hIL2/hIL2RA

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200275
Validation Data：Presence

hIL2(NM-HU-190048) was crossed with hIL2R(NM-HU-190064) to generate IhIL2/hIL2RA mice.

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