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Models

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Mice

hIL17RB(2)

Strain Name：C57BL/6Smoc-Il17rbem2(hIL17RB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200225
Validation Data：Absence

The endogenous mice Il17rb gene was replaced by human IL17RB gene. While hIL17RB(Stock No.NM-HU-200224) mice function similarly to hIL17RB(2) mice,for more detailed information please contact our technical advisor.

Mice

Ace2-KO

Strain Name：C57BL/6Smoc-Ace2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190906
Validation Data：Absence

exon 3-7 of Ace2 gene was deleted to generate Ace2 knockout mice.

Mice

hICOS(2)

Strain Name：C57BL/6Smoc-Icosem2(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190030
Validation Data：Presence

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(Stock No.NM-HU-00052) mice function similarly to hICOS(2) mice,for more detailed information please contact our technical advisor.

Mice

Fgf23-R176Q

Strain Name：C57BL/6Smoc-Fgf23em1(R176Q)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200248
Validation Data：Absence

These mice carry a p.R176Q mutation of Fgf23 gene.

Mice

Upk3b-Dre

Strain Name：C57BL/6Smoc-Upk3bem1(Dre-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200175
Validation Data：Presence

A Dre-Wpre-polyA expression cassette was knocked into the Upk3b gene start codon site.

Mice

hITGAV

Strain Name：C57BL/6Smoc-Itgavem1(hITGAV)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225043
Validation Data：Absence

The endogenous mouse Itgav gene was replaced by human ITGAV gene.

Mice

hFCGR2B/hOX40

Strain Name：C57BL/6Smoc-Fcgrt2Bem2(hFCGRT2B)Tnfrsf4em1(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200265
Validation Data：Presence

hFCGR2B（NM-HU-2000010） was crossed with hOX40（NM-HU-00041）to generate hFCGR2B/hCD40 mice

Mice

hFOXP2

Strain Name：C57BL/6Smoc-Foxp2em1(hFOXP2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210002
Validation Data：Absence

The endogenous mice Foxp2 gene was replaced by human FOXP2 gene

Mice

Clu-2A-DreERT2

Strain Name：C57BL/6Smoc-Cluem2(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200025
Validation Data：Absence

A 2A-DreERT2 expression cassette was knocked into the Clu gene stop codon site.

Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18032
Validation Data：Presence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

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