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Models

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Mice

hIL4-Tg(NMG)(2)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Tg(hIL4)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220132
Validation Data：Absence

These transgenic mice carry humanized IL4.While hIL4-Tg(NMG)(Stock No.NM-KI-215004) mice function similarly to hIL4-Tg(NMG)(2) mice, for more detailed information please contact our technical advisor.

Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057
Validation Data：Absence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

hPD-1/hPD-L1/hCD73(2)

Strain Name：C57BL/6Smoc-Pdcd1em1(hPD-1)Cd274em1(hPD-L1)Nt5eem2(hNT5E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210410
Validation Data：Absence

hPD-1(NM-HU-00015) was crossed with hPD-L1/hCD73(2)(NM-HU-210356) to generate hPD-1/hPD-L1/hCD73(2) mice.

Mice

hIL1RL2

Strain Name：C57BL/6Smoc-Il1rl2em1(hIL1RL2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215057
Validation Data：Absence

The endogenous mouse Il1rl2 gene was replaced by human IL1RL2 gene.

Mice

Vim-Cre

Strain Name：C57BL/6Smoc-Vimem(Kozak-Cre-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220105
Validation Data：Absence

Kozak-Cre-WPRE-pA expression cassette was knocked into the Vim gene start codon site.

Mice

Fbn1-C1041G

Strain Name：C57BL/6Smoc-Fbn1em1(C1041G)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200303
Validation Data：Absence

These mice carry a C1041G mutation of Fbn1 gene.

Mice

Ldlr-KO(2)

Strain Name：C57BL/6Smoc-Ldlrem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210198
Validation Data：Presence

Ldlr-KO(2) mice(Stock No.NM-KO-210198) carry a knockout allele derived from the targeted deletion of exon 4. While Ldlr-KO mice(Stock No.NM-KO-190559) carrying the exon 6-10 deletion.

Mice

Mesp1-CreERT2

Strain Name：C57BL/6Smoc-Mesp1em(CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215087
Validation Data：Absence

CreERT2-Wpre-pA expression cassette was knocked into the Mesp1 gene .

Mice

hCTLA-4(2)

Strain Name：C57BL/6Smoc-Ctla4em2(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190038
Validation Data：Absence

Extracellular domain of mouse Ctla4 gene was replaced by human CTLA4 gene. While hCTLA4(Stock No.NM-HU-00014) mice function similarly to hCTLA4(2) mice,for more detailed information please contact our technical advisor.

Mice

hPTGDR2

Strain Name：C57BL/6Smoc-Ptgdr2em1(hPTGDR2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225033
Validation Data：Presence

The endogenous mouse Ptgdr2 gene was replaced by human PTGDR2 gene.

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