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Models

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Mice

Cela1-2A-DreERT2

Strain Name：C57BL/6Smoc-Cela1em1(2A-DreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190094
Validation Data：Presence

A 2A-DreERT2 expression cassette was knocked into the Cela1 gene stop codon site.

Mice

A4gnt-KO

Strain Name：C57BL/6Smoc-A4gntem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201369
Validation Data：Absence

Exon 2-3 of A4gnt gene was deleted to generate A4gnt knockout mice.

Mice

hPD-1/hCD3E

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd3eem1(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18021
Validation Data：Absence

hPD-1（NM-HU-00015）was crossed with hCD3E（NM-HU-00114）to generate hPD-1/hCD3E。

Mice

A1cf-Flox

Strain Name：C57BL/6Smoc-A1cfem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Validation Data：Absence

These mice carry loxP sites flanking target exons of A1cf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1cf gene.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA-4

Strain Name：C57BL/6Smoc-Fcgr2bem1Fcgr3em1Fcgr4em1Ctla4em1(hCTLA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220069
Validation Data：Absence

The Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA4 mouse model was obtained by deleting all sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hCTLA4(NM-HU-00014) mouse.

Mice

hPD-L1(2)/hCCR8

Strain Name：C57BL/6Smoc-Cd274em2(hPD-L1)Ccr8em1(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210401
Validation Data：Absence

hPD-1(2)(NM-HU-190039) was crossed with hCCR8(NM-HU-190053) to generate hPD-L1(2)/hCCR8 mice.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033
Validation Data：Absence

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Atp4b-IRES-CreERT2(2)

Strain Name：C57BL/6Smoc-Atp4bem2(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210119
Validation Data：Presence

An IRES-CreERT2 expression cassette was knocked into the Atp4b gene stop codon site. Besides,An IRES-CreERT2-WPRE-pA expression cassette were knock into the Atp4b gene start codon site to generate Atp4b-IRES-CreERT2(Stock No. NM-KI-210118) mice. ATP4B could serve as a tumor suppressor in the tumorigenesis and progression. This strain is useful in studying the function of gastric parietal cells in gastric epithelial homeostasis. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cre-expressing cells after tamoxifen treatment.

Mice

hNECTIN4

Strain Name：C57BL/6Smoc-Nectin4em1(hNECTIN4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210016
Validation Data：Presence

The endogenous mice Nectin4 gene was replaced by human NECTIN4 gene.

Mice

hIL7(BALB/c)

Strain Name：BALB/cAnSmoc-Il7em1(hIL7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220014
Validation Data：Presence

The endogenous mouse Il7r gene was replaced by human IL7R gene.

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