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Models

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Mice

hCFTR

Strain Name:C57BL/6Smoc-Cftrem1(hCFTR)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225060
Validation Data:Presence

The endogenous mouse Cftr gene was replaced by human CFTR gene.

Mice

Etv1-CreERT2

Strain Name:C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200105
Validation Data:Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Trp63-CreERT2

Strain Name:C57BL/6Smoc-Trp63em(CreERT2-WPRE-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-225021
Validation Data:Presence

A CreERT2-Wpre-polyA expression cassette was knocked into the exon4 of Trp63 gene via CRISPR/Cas mediated recombination.

Mice

hFCRN(3)

Strain Name:C57BL/6Smoc-Fcgrtem3(hFCGRT)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000032
Validation Data:Absence

The endogenous mouse Fcgrt gene was replaced by human FCGRT gene. While hFCRN(Stock No.NM-HU-00109)and hFCRN(2)(Stock No.NM-HU-190070) mice function similarly to hFCRN(3) mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hSEMA4D

Strain Name:C57BL/6Smoc-Pdcd1em1(hPDCD1)Sema4dem1(hSemA4D)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190033
Validation Data:Absence

hPD-1(NM-HU-00015) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-1/hSEMA4D.

Mice

hIL11

Strain Name:C57BL/6Smoc-Il11em1(hIL11)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-204981
Validation Data:Absence

The endogenous mice Il11 gene was replaced by human IL11 gene.

Mice

hIL18

Strain Name:C57BL/6Smoc-Il18em1(hIL18)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210038
Validation Data:Presence

The endogenous mice Il18 gene was replaced by human IL18 gene.

Mice

Mc4r-KO

Strain Name:C57BL/6Smoc-Mc4rem1Smoc
Strain State:Repository Live | Cat. NO.:NM-KO-200357
Validation Data:Absence

Exon 1 of Mc4r gene was deleted to generate Mc4r knockout mice.

Mice

Il22-Cre

Strain Name:C57BL/6Smoc-Il22em1(Linker-iCre-PolyA(SV40)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200167
Validation Data:Presence

A Linker-iCre-PolyA expression cassette was knocked into the Il22 gene start codon site.

Mice

Il17c-Luc-2A-EGFP

Strain Name:C57BL/6Smoc-Il17cem1(Luc-eGFP)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-00030
Validation Data:Absence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17c.

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