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Models

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Mice

hMELTF

Strain Name：C57BL/6Smoc-Meltfem(hMELTF)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215011
Validation Data：Presence

The endogenous mouse Meltf gene was replaced by human MELTF gene.

Mice

hPD-1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00103
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hTIM3(NM-HU-00054)to generate hPD-1/hTIM3 mice

Mice

Ncr1-2A-tdTomato

Strain Name：C57BL/6Smoc-Ncr1em(P2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215075
Validation Data：Absence

P2A-tdTomato expression cassette was knocked into the Ncr1 gene .

Mice

Myf5-Cre

Strain Name：C57BL/6Smoc-Myf5em1(Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200147
Validation Data：Presence

A Cre-WPRE-polyA expression cassette was knocked into the Myf5 gene start codon site. Myogenic factor 5 (Myf5) belongs to the MRF family transcription factors that regulate myogenesis. It is expressed in the skeletal muscle and satellite cells. Severe loss of skeletal muscle following ablation of Myf5-expressing progenitors. This strain is useful in studying the differentiation of skeletal muscle.

Mice

hTIGIT(BALB/c,2)

Strain Name：BALB/cAnSmoc-Tigitem4(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200245
Validation Data：Presence

The endogenous mice Tigit gene was replaced by human TIGIT gene.While hTIGIT(BALB/c) (Stock No.NM-HU-2000043) have been pulled from shelves for some reasons.

Mice

hSIGLEC9

Strain Name：C57BL/6Smoc-Sigleceem1(hSIGLEC9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225072
Validation Data：Absence

The endogenous mouse Siglece gene was replaced by human SIGLEC9 gene.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpaem2(hSIRPA)Cd47em1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hDMPK

Strain Name：C57BL/6Smoc-Dmpkem1(hDMPK)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225084
Validation Data：Presence

The endogenous mouse Dmpk gene was replaced by human DMPK gene.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoeem3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003
Validation Data：Presence

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

hPD-1(BALB/c)

Strain Name：BALB/cAnSmoc-Pdcd1em1(hPDCD1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190079
Validation Data：Presence

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

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