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Mice

hIL4/hIL4R

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Il4ratm1(hIL4R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000106
Validation Data：Presence

These mice are obtained through breeding of two single gene humanized mice.

Mice

hCD74

Strain Name：C57BL/6Smoc-Cd74em1(hCD74)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000082
Validation Data：Absence

The endogenous mouse Cd74 gene was replaced by human CD74 gene.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

hSIGLEC15

Strain Name：C57BL/6Smoc-Siglec15em1(hSIGLEC15)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190037
Validation Data：Presence

The endogenous mouse Siglec15 gene was replaced by human SIGLEC15 gene.

Mice

hSIRPA/hCD47(BALB/c)

Strain Name：BALB/cAnSmoc-Sirpaem4(hSIRPA)SmocCd47em1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210020
Validation Data：Presence

hCD47 (NM-HU-00050) and hSRPA(2)(NM-HU-18015) were bred with BALB/c mice respectively to generate hSIRPA/hCD47(BALB/c) mice.

Mice

H2/H2-K1-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1h2em2H2-K1em2Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-006
Validation Data：Absence

Exon 2 of H2;H2-K1 gene was deleted to generate H2;H2-K1 knockout mice.

Mice

hTHPO

Strain Name：C57BL/6Smoc-Thpotm1(hTHPO)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000062
Validation Data：Absence

The endogenous mouse Thpo gene was replaced by human THPO gene.

Mice

R26-CAG-LSL-dCas9-VPR-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-dCas9-VPR-IRES-EGFP-WPRE-pA)
Strain State：Repository Live | Cat. NO.：NM-KI-18004
Validation Data：Absence

These mice harbor a CAG-LSL-dCas9-VPR(VP64-p65-Rta)-eGFP-pA conditional expression cassette in mouse Rosa26 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

hTROP2

Strain Name：C57BL/6Smoc-Tacstd2em(hTACSTD2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-215022
Validation Data：Presence

The endogenous mice Tacstd2 gene was replaced by human TACSTD2 gene.

Mice

Crbn-I391V/Rag2-KO

Strain Name：C57BL/6Smoc-Crbnem1(I391V)Rag2em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210398
Validation Data：Absence

Crbn-I391V(NM-KI-200331) was crossed with Rag2-KO(NM-KO-190429) to generate Crbn-I391V/Rag2-KO mice.

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