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Models

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Mice

hIL11RA

Strain Name：C57BL/6Smoc-Il11ra1em1(hIL11RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204982
Validation Data：Absence

The endogenous mice Il11ra1 gene was replaced by human IL11RA gene.

Mice

hCD45

Strain Name：C57BL/6Smoc-Ptprcem1(hPTPRC)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225080
Validation Data：Presence

The endogenous mouse Ptprc gene was replaced by human PTPRC gene.

Mice

hFAS

Strain Name：C57BL/6Smoc-Fasem1(hTNFRSF6)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210007
Validation Data：Presence

The endogenous mice Fas gene was replaced by human FAS gene.

Mice

Bmi1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Bmi1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200095
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Bmi1 gene stop codon site.

Mice

hTNFR2/hFCGR2B

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Fcgr2bem3(FCGR2B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210404
Validation Data：Absence

hTNFRSF1B (NM-HU-190010) was crossed with hFCGR2B (NM-HU-2000010) to generate hTNFRSF1B/hFCGR2B mice.

Mice

hCD3E/hSDC1

Strain Name：C57BL/6Smoc-Cd3eem1(hCD3E)Sdc1em1(hSDC1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220021
Validation Data：Absence

hCD3E(NM-HU-00114) was crossed with hSDC1(NM-HU-2000026) to generate hCD3E/hSDC1 mice.

Mice

Prkdc/Il2rg-KO(NOD)

Strain Name：NOD-Prkdcem1 Il2rgem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00158
Validation Data：Absence

Prkdc and Il2rg double knockout mice were generated.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001
Validation Data：Presence

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

hPD-L1/hVISTA

Strain Name：C57BL/6Smoc-Visrem1(hVSIR)Cd274em1(hCD274)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000094
Validation Data：Absence

hPD-L1(NM-HU-00062) was crossed with hVISTA(NM-HU-00118) to generate hPD-L1/hVISTA.

Mice

hTP53(2)

Strain Name：C57BL/6Smoc-Trp53em2(hTP53)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225052
Validation Data：Presence

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

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