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Models

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Mice

C9orf72-KO

Strain Name：C57BL/6Smoc-C9orf72em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201246
Validation Data：Absence

Exon 4-5 of C9orf72 gene was deleted to generate C9orf72 knockout mice.

Mice

hSIGLEC8(2)

Strain Name：C57BL/6Smoc-Siglecfem1(hSIGLEC8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210033
Validation Data：Presence

The endogenous mice Siglecf gene was replaced by human SIGLEC8 gene. While hSIGLEC8(Stock No.NM-HU-204983) mice function similarly to hSIGLEC8(2) mice,for more detailed information please contact our technical advisor.

Mice

Adipoq-IRES-Dre

Strain Name：C57BL/6Smoc-Adipoqem(IRES-Dre)1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225055
Validation Data：Absence

IRES-Dre expression cassette was knocked into the Adipoq gene .

Mice

Avil-Cre

Strain Name：C57BL/6Smoc-Avilem1(Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215036
Validation Data：Presence

Cre expression cassette was knocked into the Avil gene.

Mice

Il17a-2A-CreERT2

Strain Name：C57BL/6Smoc-Il17aem1(2A-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00059
Validation Data：Absence

A 2A-Cre cassette was inserted before stop codon of mouse Il17a gene which is known as a T cell marker.

Mice

Ucp1-CreERT2

Strain Name：C57BL/6Smoc-Ucp1em1(Kozak-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190102
Validation Data：Presence

A Kozak-CreERT2-WPRE-polyA expression cassette was knocked into the Ucp1 gene start codon site.

Mice

Tert-CreERT2-2A-EGFP

Strain Name：C57BL/6Smoc-Tertem1(CreERT2-2A-GFP-WPRE-PA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18037
Validation Data：Presence

A CreERT2-2A-GFP-WPRE-PA expression cassette was knocked into the Telt gene start codon site by homologous recombination.

Mice

Bhlha15-CreERT2

Strain Name：C57BL/6Smoc-Bhlha15em1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200080
Validation Data：Presence

The coding region of Bhlha15 gene was replaced by a CreERT2 expression cassette.Besides,a kozak-CreERT2-WPRE-polyA expression cassette were knock into the Bhlha15 gene start codon site to generate Bhlha15-CreERT2(2)(Stock No. NM-KI-200158) mice. Bhlha15(basic helix-loop-helix family member a15) is also known as Mist1. The gene product is involved in controlling exocrine secretion from the pancreas, small intestine and stomach. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Bhlha15.

Mice

Slco1c1-2A-CreERT2

Strain Name：C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200262
Validation Data：Presence

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.

Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoeem4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013
Validation Data：Presence

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

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