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Models

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Mice

hCFB

Strain Name：C57BL/6Smoc-Cfbem1(hCFB)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000078
Validation Data：Presence

The endogenous mouse Cfb gene was replaced by human CFB gene.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6em1(hIL6)Il6raem1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIFNGR1

Strain Name：C57BL/6Smoc-Ifngr1em(hIFNGR1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190076
Validation Data：Presence

The endogenous mouse Ifngr1 gene was replaced by human IFNGR1 gene.

Mice

hCD3E(2)

Strain Name：C57BL/6Smoc-Cd3eem2(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210023
Validation Data：Absence

The endogenous mice Cd3e gene was replaced by human CD3E gene. While hCD3E(Stock No.NM-HU-00114) mice function similarly to hCD3E(2) mice,for more detailed information please contact our technical advisor.

Mice

Isl1-CreERT2

Strain Name：C57BL/6Smoc-Isl1em1(CreERT2) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00013
Validation Data：Presence

CreERT2 was inserted at the start codon (ATG site). The KI mice have a tamoxifen-inducible cre-mediated recombination system.

Mice

Cd2-2A-CreERT2

Strain Name：C57BL/6Smoc-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18017
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

Map2-2A-CreERT2

Strain Name：C57BL/6Smoc-Map2em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00037
Validation Data：Presence

Map2 is a marker of mature neurons. A 2A-CreERT2 cassette was inserted before the translational termination site of the Map2 locus.

Mice

hCCR8(2)/hTIGIT

Strain Name：C57BL/6Smoc-Tigitem3(hTIGIT)Ccr8em3(hCCR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220073
Validation Data：Absence

hTIGIT(NM-HU-200244) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hTIGIT/hCCR8 mice．

Mice

hGIPR

Strain Name：C57BL/6Smoc-Giprem2(hGIPR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225064
Validation Data：Presence

The endogenous mouse Gipr gene was replaced by human GIPR gene.

Mice

G6pc-Flox

Strain Name：C57BL/6Smoc-G6pcem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200053
Validation Data：Absence

These mice carry loxP sites flanking exon 3 of G6pc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc gene.

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