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Models

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Mice

hIL2RB/hPD-1

Strain Name：C57BL/6JSmo-Il2rbtm1(hIL2RB)Pdcd1tm1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220036

hIL2RB(NM-HU-2000055) mice were crossed with hPD-1(NM-HU-00015) to generate hIL2RB/hPD-1 mice.

Mice

Myh11-2A-DreERT2

Strain Name：C57BL/6JSmo-Myh11em1(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190037
Publications：1piece

A 2A-DreERT2 expression cassette was knocked into the Myh11 gene stop codon site.

Mice

Park7-KO

Strain Name：C57BL/6JSmo-Park7em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191006

Exon 3-5 of Park7 gene was deleted to generate Park7 knockout mice.

Mice

Dmp1-KO

Strain Name：C57BL/6JSmo-Dmp1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200634

Exon 4-6 of Dmp1 gene was deleted to generate Dmp1 knockout mice.

Mice

A3galt2-Flox

Strain Name：C57BL/6Smoc-A3galt2em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253844

These mice carry loxP sites flanking exon 2-4 of A3galt2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A3galt2 gene.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sortm1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Opn4-Cre

Strain Name：C57BL/6JSmo-Opn4em1(Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200304
Validation Data：Presence

Cre-WPRE-polyA expression cassette was knocked into the Opn4 gene start codon site. The melanopsin gene (Opn4) encodes a functional photopigment. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying circadian rhythm regulation.

Mice

Ptger3-2A-Cre

Strain Name：C57BL/6JSmo-Ptger3em(2A-Cre)1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225027

2A-Cre expression cassette was knocked into the Ptger3 gene .

Mice

A3galt2-KO

Strain Name：C57BL/6JSmoc-A3galt2em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-261745

The exon 2-4 of A3galt2 gene was deleted to generate A3galt2 knockout mouse.

Mice

hIL4/hIL4R(BALB/c)

Strain Name：BALB/cJSmo-Il4tm3(hIL4)Il4ratm1(hIL4RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220167
Validation Data：Presence

The endogenous mouse Il4,Il4ra gene was replaced by human IL4 gene.

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