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Models

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Mice

hPD-L2(BALB/c)

Strain Name：BALB/cJSmo-Pdcd1lg2tm1(hPDCD1LG2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190061

The endogenous mouse Pdcd1lg2 gene was replaced by human PDCD1LG2 gene.

Mice

Ifnar1-KO

Strain Name：C57BL/6JSmo-Ifnar1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18038

The Ifnar1 knockout mouse model was obtained by knocking out the exon 3-11 region of mouse Ifnar1 gene.

Mice

hSIRPA(BALB/c,2)

Strain Name：BALB/cJSmo-Sirpatm(hSIRPA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210369

The endogenous mice Sirpa gene was replaced by human SIRPA gene.While hSIRPA(BALB/c)(Stock No.NM-HU-2000041) mice function similarly to hSIRPA(BALB/c,2) mice, for more detailed information please contact our technical advisor.

Mice

hIL21R

Strain Name：C57BL/6JSmo-Il21rtm1(hIL21R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210031
Validation Data：Presence

The endogenous mice Il21r gene was completely or partially replaced by human IL21R gene via ESC targeting.

Mice

hCD47/hSIRPA(2)(BALB/c)

Strain Name：BALB/cJSmo-Sirpatm4(hSIRPA)SmocCd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210020
Validation Data：Presence

hCD47 (NM-HU-00050) and hSRPA(2)(NM-HU-18015) were bred with BALB/c mice respectively to generate hSIRPA/hCD47(BALB/c) mice.

Mice

hPD-L1/hOX40

Strain Name：C57BL/6JSmo-Cd274tm1(hPD-L1)Tnfrsf4tm1(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00111

hPD-L1（NM-HU-00062）was crossed with hOX40（NM-HU-00041）to generate hPD-L1/hOX40.

Mice

hICOS/hICOSL

Strain Name：C57BL/6JSmo-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Cd2-2A-CreERT2

Strain Name：C57BL/6JSmo-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18017
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

Aldh5a1-KO

Strain Name：C57BL/6JSmo-Aldh5a1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201238

Exon 3-7 of Aldh5a1 gene was deleted to generate Aldh5a1 knockout mice.

Mice

Aldob-KO

Strain Name：C57BL/6JSmo-Aldobem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200602

Exon 3-6 of Aldob gene was deleted to generate Aldob knockout mice.

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