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Models

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Mice

hIL23A(BALB/c)

Strain Name：BALB/cJSmo-Il23atm3(hIL23A)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220013
Validation Data：Presence

The endogenous mouse Il23a gene was replaced by human IL23A gene.

Mice

hSERPINC1

Strain Name：C57BL/6JSmo-Serpinc1tm1(hSERPINC1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225075
Validation Data：Presence

The endogenous mouse Serpinc1 gene was replaced by human SERPINC1 gene.

Mice

Il18-Luc-2A-EGFP

Strain Name：C57BL/6JSmo-Il18em1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00032
Validation Data：Presence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il18.

Mice

Tnnt2-dCreERT2

Strain Name：C57BL/6JSmo-Tnnt2em1(rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200015

A rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA expression cassette was knocked into the Tnnt2 gene start codon site.

Mice

hCD47/hSIRPA(2)

Strain Name：C57BL/6JSmo-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hPD-1/hPD-L1(2)/hCCR8

Strain Name：C57BL/6JSmo-Pdcd1tm1(hPDCD1)Cd274tm2(hPD-L1)Ccr8tm1(hCCR8)/Smoc
Strain State：Developing | Cat. NO.：NM-HU-210402

hPD-1(NM-HU-00015) and hPD-1(2)(NM-HU-190039) were crossed with hCCR8(NM-HU-190053) to generate hPD-1/hPD-L1(2)/hCCR8 mice.

Mice

Car4-DreERT2

Strain Name：C57BL/6JSmo-Car4em1(DreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200193

A DreERT2-Wpre-pA expression cassette was knocked into the Car4 gene start codon site.

Mice

hIL2/hIL2RA(BALB/c)

Strain Name：BALB/cJSmo-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220018
Validation Data：Presence

The endogenous mouse Il2 and Il2ra gene was replaced respectively by human IL2 and IL2RA gene.

Mice

hPD-L1/hCD27(2)

Strain Name：C57BL/6JSmo-Cd274tm1(hPD-L1)Cd27tm3(hCD27)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200274

hPD-L1(NM-HU-00062) was crossed with hCD27(2)(NM-HU-190035)to generate hPD-L1/hCD27(2) mice.While hPD-L1/hCD27 (Stock No.NM-HU-18023) have been pulled from shelves for some reasons.

Mice

Slc17a6-CreERT2

Strain Name：C57BL/6JSmo-Slc17a6em2(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190011
Validation Data：Presence

This tamoxifen-inducible Slc17a6-CreERT2 tool mouse model was established by inserting a 2A-CreERT2-WPRE-polyA co-expression cassette into the stop codon of Slc17a6 gene.

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