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Models

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Mice

hCXCR3

Strain Name：C57BL/6JSmo-Cxcr3tm1(hCXCR3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200219
Validation Data：Presence

The endogenous mouse Cxcr3 gene was completely or partially replaced by human CXCR3 gene via ESC targeting.

Mice

hIL18BP

Strain Name：C57BL/6JSmo-Il18bptm1(hIL18BP)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210039
Validation Data：Presence

The endogenous mice Il18bp gene was replaced by human IL18BP gene.

Mice

hTIGIT(BALB/c,2)

Strain Name：BALB/cJSmo-Tigittm4(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200245
Validation Data：Presence

The endogenous mice Tigit gene was replaced by human TIGIT gene.While hTIGIT(BALB/c) (Stock No.NM-HU-2000043) have been pulled from shelves for some reasons.

Mice

Cd79a-2A-Cre

Strain Name：C57BL/6JSmo-Cd79aem(2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220089
Validation Data：Presence

2A-Cre expression cassette was knocked into the Cd79a gene stop codon site.

Mice

Foxp3-IRES-tdTomato-2A-Cre

Strain Name：C57BL/6JSmo-Foxp3em3(IRES-tdTomato-2A-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190119
Validation Data：Presence

A IRES-tdTomato-2A-Cre expression cassette was knocked into the Foxp3 gene stop codon site. This strain is useful in studying regulatory T cell in autoimmunity, especially in type 1 diabetes.

Mice

R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

Mice

hMELTF

Strain Name：C57BL/6JSmo-Meltftm(hMELTF)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215011
Validation Data：Presence

The endogenous mouse Meltf gene was replaced by human MELTF gene.

Mice

hLAG3(BALB/c)

Strain Name：BALB/cJSmo-Lag3tm1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000051

The endogenous mouse Lag3 gene was replaced by human LAG3 gene.

Mice

hPSGL-1(2)

Strain Name：C57BL/6JSmo-Selplgtm2(hSELPLG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210026
Validation Data：Presence

The endogenous mice Selplg gene was completely or partially replaced by human SELPLG gene via CRISPR/Cas9 mediated recombination.

Mice

Il17b-Luc-2A-EGFP

Strain Name：C57BL/6JSmo-Il17bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00029

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17b.

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