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Models

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Mice

hTLR4

Strain Name：C57BL/6JSmo-Tlr4tm2(hTLR4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000025
Validation Data：Presence

The endogenous mouse Tlr4 gene was replaced by human TLR4 gene.

Mice

hSIGLEC8

Strain Name：C57BL/6JSmo-Siglecetm1(hSIGLEC8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204983

The endogenous mice Siglece gene was replaced by human SIGLEC8 gene. While hSIGLEC8(2)(Stock No.NM-HU-210033) mice function similarly to hSIGLEC8 mice,for more detailed information please contact our technical advisor.

Mice

hCD73(2)

Strain Name：C57BL/6JSmo-Nt5etm3(NT5E)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200009
Validation Data：Presence

The endogenous mouse Nt5e gene was replaced by human NT5E gene.

Mice

hGDF15

Strain Name：C57BL/6JSmo-Gdf15tm(hGDF15)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215002
Validation Data：Presence

The endogenous mice Gdf15 gene was replaced by human GDF15 gene.

Mice

Cx3cr1-CreERT2

Strain Name：C57BL/6JSmo-Cx3cr1em1(creERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200157
Validation Data：Presence

A creERT2-WPRE-polyA expression cassette was knocked into the Cx3cr1 gene start codon site.

Mice

Trp53-Flox

Strain Name：C57BL/6JSmo-Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18005
Publications：1piece

These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hPD-L1/hCD40

Strain Name：C57BL/6JSmo-Cd274tm1(hPD-L1)Cd40tm1(hCD40)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18024

hPD-L1(NM-HU-00062) was crossed with hCD40(NM-HU-00076) to generate hPD-L1/hCD40.

Mice

hHLA-DPB1*04: 01

Strain Name：C57BL/6JSmo-H2-Ab1tm1(hHLA-DPB1*04: 01)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210011
Validation Data：Presence

The endogenous mice H2-Ab1 gene was replaced by human HLA-DPB1*04:01 gene.

Mice

hSOD1

Strain Name：C57BL/6JSmo-Sod1tm1(hSOD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225056
Validation Data：Presence

The endogenous mouse Sod1 gene was replaced by human SOD1 gene.

Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6JSmo-Foxn1em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200106
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

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