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Models

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Mice

R26-CreERT2

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200041
Validation Data：Presence

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

Mice

C4b-KO

Strain Name：C57BL/6JSmo-C4bem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190761

Exon 3 of C4b gene was deleted to generate C4b knockout mice.

Mice

hCD248

Strain Name：C57BL/6JSmo-Cd248tm1(hCD248)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225028

The endogenous mouse Cd248 gene was replaced by human CD248 gene.

Mice

hSPP1

Strain Name：C57BL/6JSmo-Spp1tm1(hSPP1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225037
Validation Data：Presence

The endogenous mouse Spp1 gene was replaced by human SPP1 gene.

Mice

Foxp3-V5-AviTag-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6JSmo-Foxp3em1(V5-AviTag-IRES-luci-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18034

A V5-AviTag-IRES-luci-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled knockin model with V5, Avi, luciferase and tdTomato fluorescent protein.

Mice

Slco1c1-2A-CreERT2

Strain Name：C57BL/6JSmo-Slco1c1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200262
Validation Data：Presence

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.

Mice

Cck-IRES-Cre

Strain Name：C57BL/6JSmo-Cckem1(IRES-iCre-PolyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200131
Validation Data：Presence

A IRES-iCre-PolyA expression cassette was knocked into the Cck gene stop codon site.

Mice

Foxp3-DreERT2

Strain Name：C57BL/6JSmo-Foxp3em5(IRES-DreER)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200198

A IRES-DreER expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

hMASP2

Strain Name：C57BL/6JSmo-Masp2tm1(hMASP2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000076
Validation Data：Presence

The endogenous mouse Masp2 gene was replaced by human MASP2 gene.

Mice

hSIGLEC15(BALB/c)

Strain Name：BALB/cJSmo-Siglec15tm2(hSIGLEC15) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200001
Validation Data：Presence

The endogenous mouse Siglec15 gene was replaced by human SIGLEC15 gene .

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