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Models

About 202 results
Mice

Il34-KO

Strain Name：C57BL/6Smoc-Il34em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190501

Exon 3 of Il34 gene was deleted to generate Il34 knockout mice.

Mice

Ranbp2-Flox

Strain Name：C57BL/6Smoc-Ranbp2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200030

These mice carry loxP sites flanking exon 3 of Ranbp2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ranbp2 gene.

Mice

Ninj1-KO

Strain Name：C57BL/6Smoc-Ninj1em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200615

Exon 2 of Ninj1 gene was deleted to generate Ninj1 knockout mice.

Mice

Sec31a-KO

Strain Name：C57BL/6Smoc-Sec31aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200470

Exon 3 of Sec31a gene was deleted to generate Sec31a knockout mice.

Mice

Ctnnb1-Flox

Strain Name：C57BL/6Smoc-Ctnnb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200154

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.

Mice

Dicer1-Flox

Strain Name：C57BL/6Smoc-Dicer1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200158

These mice carry loxP sites flanking exon 23 of Dicer1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dicer1 gene.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Trp53-KO

Strain Name：B6.129-Trp53tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00011

A neo cassette replaces exons 2-11,including the start codon,of Trp53 (transformation related protein 53).Null homozygotes show high, early-onset tumor incidence;some have persistent hyaloid vasculature and cataracts.

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