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Ern2-KO

Strain Name：C57BL/6Smoc-Ern2^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201554

Exon 3 of Ern2 gene was deleted to generate Ern2 knockout mice.

Olfr458-Flox

Strain Name：C57BL/6Smoc-Olfr458^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Olfr458 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Olfr458 gene.

Olfr458-KO

Strain Name：C57BL/6Smoc-Olfr458^em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 1 of Olfr458 gene was deleted to generate Olfr458 knockout mice.

Mir27a-KO(SD)

Strain Name：SD-Mir27a^em1Smoc Strain State：Developing | Cat. NO.：NR-KO-242382

The exon 1 of Mir27a gene was deleted to generate Mir27a knockout rat.

Onconase downregulates microRNA expression through targeting microRNA precursors

Model Organisms：细胞 Product & Service：N/A Research field：Mechanism

miR-21

miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair

Model Organisms：小鼠 Product & Service：- Research field：

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.