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Models

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Mice

Nkx2-5-V142I-EGFP

Strain Name：C57BL/6Smoc-Nkx2-5em1(V142I-Linker-EGFP-WPRE-pA)Smoc
Strain State：Developing | Cat. NO.：NM-KI-232300

The V142I-Linker-EGFP-WPRE-pA expression cassette was knocked into the Nkx2-5 gene stop codon site.

Mice

hHLA-A24.2/B2M

Strain Name：C57BL/6Smoc-H2-D1em1(hB2M-linker-HLA-A24.2)Smoc
Strain State：Developing | Cat. NO.：NM-HU-241051

The endogenous mouse H2-D1 gene was replaced by human B2M gene.

Mice

hHLA-A11.1/B2M

Strain Name：C57BL/6Smoc-H2-K1tm1(hB2M-linker-HLA-A*1101)Smoc
Strain State：Developing | Cat. NO.：NM-HU-241355

The endogenous mouse H2-K1 gene was replaced by hB2M-linker-HLA-A*1101 gene.

Mice

hHLA-A2.1/B2M(3)

Strain Name：C57BL/6Smoc-H2-D1em3(hB2M-linker-HLA-A2.1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-250280

The endogenous mouse H2-D1 gene was replaced by hB2M-linker-HLA-A2.1 gene.

Mice

R26-CAG-LSL-Coro1a

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Coro1a-linker-3xFlag-HA-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-215009

A CAG-LSL-Coro1a-linker-3xFlag-HA-WPRE-pA expression cassette was knocked into the Rosa26 locus.

Mice

hHLA-A2.1/B2M(NMG)(2)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1B2mem1(hB2M-linker-HLA-A*0201/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-241683

The endogenous mouse B2m gene was replaced by hB2M/HLA-A2.1/H2-D1 gene.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

mB2m-hFCRN(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1Fcgrtem1(B2m-FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-018

A B2m-Linker-FCGRT-WPRE-polyA expression cassette was knocked into the Fcgrt gene exon3 of the NMG(NM-NSG-001) mice.

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

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