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Models

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Mice

Xcr1-IRES-Cre

Strain Name：C57BL/6Smoc-Xcr1em1(IRES-iCre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200237
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Xcr1 gene stop codon site.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Cd68-IRES-CreERT2

Strain Name：C57BL/6Smoc-Cd68em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200162

A IRES-CreERT2 expression cassette was knocked into the Cd68 gene stop codon site.

Mice

S100a4-2A-CreERT2

Strain Name：C57BL/6Smoc-S100a4em1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200024
Validation Data：Presence

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the S100a4 gene stop codon site.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sortm1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Ptf1a-CreERT2

Strain Name：C57BL/6Smoc-Ptf1aem1(CreERT2-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200118
Validation Data：Presence

A CreERT2-WPRE-pA expression cassette was knocked into the Ptf1a gene start codon site.

Mice

Krt14-2A-DreERT2

Strain Name：C57BL/6Smoc-Krt14em3(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190125
Validation Data：Presence  |  Publications：1piece

A 2A-DreERT2 expression cassette was knocked into the Krt14 gene stop codon site.

Mice

Pvalb-2A-Cre

Strain Name：C57BL/6Smoc-Pvalbem1(T2A-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200098
Validation Data：Presence

A T2A-iCre expression cassette was knocked into the Pvalb gene stop codon site.

Mice

Drd1-2A-CreERT2

Strain Name：C57BL/6Smoc-Drd1em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18016
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Drd1 gene via homologous recombination to establish a tamoxifen inducible Drd1-CreERT2 tool stain. This strain can be used to knockout target gene in Drd1+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

Il22-Cre

Strain Name：C57BL/6Smoc-Il22em1(Linker-iCre-PolyA(SV40)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200167
Validation Data：Presence

A Linker-iCre-PolyA expression cassette was knocked into the Il22 gene start codon site.

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