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How do I breed conventional knockout mice or genetically mutated mice? How do I choose control mice for experiments?

genetically mutated neo gene phenotype definition

Genotyping method for CRISPR/Cas9 point mutation mouse

Genotyping method for CRISPR/Cas9 Knockout mouse

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

Database

mouse genome database

Here you can find links to databases for mouse genomes and other resources.

Popular Model Organisms

genetically modified organisms transgenic organisms genetically modified organisms examples

Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

P53 CKO Mouse Model

p53 knockout p53 knockout mice p53 gene

Our own-developed mouse model of p53 conditional knockout (p53-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of p53 in specific tissues or cells. These mice can be used for tumorigenesis and tumor mechanistic studies.

Brca1 CKO Mouse Model

Our own-developed Brca1 conditional knockout mice (Brca1-CKO) can be used to study breast cancer.

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Pten CKO Mouse Model

Our own-developed mouse model of Pten conditional knockout (Pten-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of Pten in specific tissues or cells, thus avoiding the embryonic death caused by systemic and homozygous Pten knockout. Pten-CKO mice can be used to study tumorigenesis, anti-tumor targets, neurogenesis, glial differentiation and cerebellar development.