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Fluorescent tracking

fluorescent label fluorescent tag fluorescent genes

Exogenous fluorescent genes were knocked in to endogenous genes and fluorescence expression was used to reflect the expression status of genes.

Phenotyping

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Provide blood analysis, image analysis, pathology analysis, behavior analysis etc.

P53 CKO Mouse Model

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Our own-developed mouse model of p53 conditional knockout (p53-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of p53 in specific tissues or cells. These mice can be used for tumorigenesis and tumor mechanistic studies.

Customization

Using SMOC’s gene targeting artificial intelligent expert system-Smarteddi, you can input the name of the gene you want to knockout and the cloud-based search engine will show you the solution. 

Type of genetic engineering

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Three types of genetic modification by the gene engineered technology: gene knockout. gene knock-in, gene overexpression.

Popular Model Organisms

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Model Repository

model repository

Shanghai Model Organisms has established more than 18,000 genetically modified mouse models using three core technologies of gene editing. It has more than 10,000 proprietary genetically engineered mouse models that can be directly used for studies on gene functions, drug screening, and human diseases. At the same time, Shanghai Model Organisms has more than 30 fluorescent-labeled tumor cell lines, which can be used for in vitro experiments, studies on tumor bearing mice and other tumor researches.

U-GEMM Repository

The U-GEMM Repository has more than 6000 Genetically Engineered Mice & Rat Models, including KO , Flox，Cre/Dre, gene humanized knockin, Immunodeficiency, reporter Knockin , genetic disease and other models. You can Search for Mouse & Rat Models by Name, Catalog Number or Keyword.

Inflammation Models

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Inflammation is a common yet important pathological process. Any factor that may cause tissue damage can lead to inflammation. Anomal inflammatory response may result in chronic inflammation, autoimmune diseases and even cancer. The regulation of inflammation-related genes is an important topic in the study of the development of inflammation.

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.