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Gene Knockout

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Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Gene Knock-in

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Knock-in represents the introduction of specific mutations or exogenous genes, such as point mutations (mimicking human genetic disease) at the selected location or reporter genes (e.g., EGFP, RFP, mCherry, YFP, LacZ, Luciferase etc.) or functional cDNAs (such as Cre, Dre etc.) into a specific genomic locus through homologous recombination, thereby allowing the exogenous DNA fragment to be expressed. A simultaneous occurrence of knock-in and knock-out can be achieved by replacing a murine endogenous gene with a foreign DNA fragment.

Gene overexpression

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Generate a mouse model in which an exogenous gene is introduced and overexpressed. An overexpression model can be used to investigate gene functions, promoter functions, or model the pathogenesis of human disease. Depending on the method to introduce foreign DNA, a random transgenes or targeted conditional overexpression model can be created.

Gene Expression/Protein Analysis

protein expression analysis Gene expression analysis

Shanghai Model Organisms provides high-quality gene and protein expression analysis services, including RT-PCR, real time PCR, and Western blot, with accurate experimental results that can be used for publication.

Gene tracking

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Gene tracers are an important application for genetically engineered mice. Through gene knock-in, exogenous tracer genes were knocked into endogenous genes, enabling labeling and tracing of genes.

Gene-editing proposal

model mouse

Using SMOC’s gene targeting artificial intelligent expert system-Smarteddi, you can input the name of the gene you want to knockout and the cloud-based search engine will show you the solution.

Study of Gene Functions

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Overview of gene editing technology

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Hemophilia Model

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The F8 and F9 gene knockout mice were generated by Shanghai Model Organisms Center (SMOC)

Dysgenesis model

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Prss37 gene knockout infertility mouse model. SMOC has developed the Prss37 gene knockout mouse model (Prss37 KO, Model No.: NM -KO-00016) by ES cell targeting. It is a homozygous male infertility model.