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Models

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Mice

F9-KO

Strain Name:C57BL/6Smoc-F9em1Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-18046

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046)carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Mice

huPBMC-(NMG)

Strain Name:huPBMC-(NMG)
Strain State:Repository Live | Cat. NO.:NM-NSG-015

NMG mice are injected with human peripheral blood mononuclear cells (huPBMCs).

Mice

huHSC-(NMG)

Strain Name:huHSC-(NMG)
Strain State:Repository Live | Cat. NO.:NM-NSG-017

After irradiation, NMG mice are injected with CD34+ hematopoietic stem cells (CD34+ HSC).

Mice

hIL21R

Strain Name:C57BL/6Smoc-Il21rtm1(hIL21R)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210031

The endogenous mice Il21r gene was completely or partially replaced by human IL21R gene via ESC targeting.

Mice

hANGPTL3(4)

Strain Name:C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210036

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

hEPCAM

Strain Name:C57BL/6Smoc-EpCAMtm1(hEpCAM)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210032

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.

Mice

hVSIG4

Strain Name:C57BL/6Smoc-Vsig4em1(hVSIG4)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210004

The endogenous mice Vsig4 gene was replaced by human VSIG4 gene

Mice

hCD3E(2)

Strain Name:C57BL/6Smoc-Cd3eem2(hCD3E)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210023

The endogenous mice Cd3e gene was replaced by human CD3E gene. While hCD3E(Stock No.NM-HU-00114) mice function similarly to hCD3E(2) mice,for more detailed information please contact our technical advisor.

Mice

hCD47(Balb/c,2)

Strain Name:BALB/cAnSmoc-Cd47em1(hCD47)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210359

The endogenous mice Cd47 gene was replaced by human CD47 gene. While hCD47(BALB/c)(Stock No.NM-HU-2000022) mice function similarly to hCD47(BALB/c,2) mice, for more detailed information please contact our technical advisor.

Mice

hFAS

Strain Name:C57BL/6Smoc-Fasem1(hTNFRSF6)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210007

The endogenous mice Fas gene was replaced by human FAS gene.

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