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Trp53-KO/Kras-G12D

Strain Name：Trp53-KO/Kras-G12D
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD08
Validation Data：Presence

Trp53-KO/Kras-G12D cell line is murine cell derived from lung cancer model of the offspring produced by mating Trp53-Flox mice (NM-CKO-18005) and Kras-LSL-G12D mice (NM-KI-190003).

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

Model Organisms：Mouse Product & Service：Dhhc4.Dhhc5 Research field：metabolism

HIF-1alpha and HIF-2alpha induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Model Organisms：斑马鱼 Product & Service：HIF-2alpha Research field：Drug screening and drug mechanism

血管生成 Thalidomide 血管内皮生长因子 VEGF

Dual Cre and Dre recombinases mediate synchronized lineage tracing and cell subset ablation in vivo.

Model Organisms：小鼠 Product & Service：R26-CAG-LSL-RSR-tdTomato-2A-DTR Research field：DTR mice

Palladin regulates cell and extracellular matrix interaction through maintaining normal actin cytoskeleton...

Model Organisms：细胞 Product & Service：Palld Research field：Cytoskeleton

细胞外基质

The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in...

Model Organisms：小鼠 Product & Service：hACE2 Research field：SARS-CoV-2

Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH-...

Model Organisms：Mouse Product & Service：Drp1 Research field：Ischemic injury

HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes...

Model Organisms：小鼠 Product & Service：HCCS Research field：Liver

凋亡调控

The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and...

Model Organisms：Mouse Product & Service：slc39a5 Research field：Trace element

4-Phenylbutyrate restored γ-aminobutyric acid uptake and reduced seizures in SLC6A1 patient variant-bearing cell and...

Model Organisms：小鼠 Product & Service：Slc6a1-S295L(NM-KI-190014) Research field：Rare disease