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Models

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Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Slc6A12-KO

Strain Name：B6;129S-Slc6a12tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00047

Exon 1 and exon 2 were replaced by Neo cassette.

Mice

Btbd10-KO

Strain Name：B6;129S-Btbd10tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00043

Exon 6 and exon 7 were replaced by Neo cassette.

Mice

Eif4ebp1-KO

Strain Name：C57BL/6Smoc-Eif4Ebp1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191088

Exon 1 and exon 2 of Eif4ebp1 gene was deleted to generate Eif4ebp1 knockout mice.

Mice

Gpr61-KO

Strain Name：B6;129S-Gpr61tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00060

Exon 2 and exon 3 were replaced by Neo cassette.

Mice

Gpr142-KO

Strain Name：B6;129S-Gpr142tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00058

Exon 1 and exon 2 were replaced by Neo cassette.

Mice

Mir29b2/Mir29c-KO

Strain Name：C57BL/6Smoc-Mir29b-2em1 Mir29cem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00080

Mir29b-2 and Mir29c are located in 3'UTR region of Cd46 gene. a 0.7kb region in length including Mir29b-2 and Mir29c pre-microRNAs was removed in this strain.

Mice

Mir29a/Mir29b-1-KO

Strain Name：C57BL/6Smoc-Mir29aemMir29b-1emSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-220479

The Mir29a and Mir29b-1 gene were deleted to generate Mir29a,Mir29b-1 knockout mice.

Mice

hOX40(2)

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00078
Validation Data：Presence

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

Mice

Mycn-TRE-EGFP

Strain Name：B6;129S-Mycntm1(TRE-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00008

A TRE site and a loxp EGFP casette were inserted into introns 1-2 to create a Dox-inducible N-myc gene silence mice.

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