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Mice

Rag2/IL2rg-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210231
Validation Data：Presence

Exon 3 of Rag2 and exon 2 of IL2rg gene was deleted to generate Rag2 and IL2rg knockout mice.

Mice

hIL3-hCSF2-Tg(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Tg(hIL3-hCSF2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215006
Validation Data：Presence

These transgenic mice carry humanized IL3 and humanized CSF2.

Mice

Ern1-Flox

Strain Name：B6;129S-Ern1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00077
Publications：1piece

An frt-neo-frt cassette was inserted after exon 2 and loxP sites was inserted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

hFCRN(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgrttm2(FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-020
Validation Data：Presence

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

Mice

Cdkn2a-Flox(p16/p19-Flox)

Strain Name：C57BL/6Smoc-Cdkn2aem3(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200015
Publications：1piece

These mice carry loxP sites flanking exon 2 of the common region of Cdkn2a-p19ARF and Cdkn2a-p16INK4a transcripts.

Mice

C57BL/6

Strain Name：C57BL/6
Strain State：Repository Live | Cat. NO.：SM-001
Validation Data：Presence

It was the first mouse strain to have its genome sequenced. With black coat color, it is recognized as the "standard" inbred strain and provides genetic background for numerous mutant genes. It is characterized by stable strain properties, ease of breeding, uniform stress responses, and high precision in experimental results.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

ICR

Strain Name：ICR
Strain State：Repository Live | Cat. NO.：SM-006
Validation Data：Presence

ICR

Mice

hCD20(2)

Strain Name：C57BL/6Smoc-Ms4a1tm3(hCD20)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200114
Validation Data：Presence

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.

Mice

Prkdc/Il2rg-KO(NOD)

Strain Name：NOD-Prkdcem1 Il2rgem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00158

Prkdc and Il2rg double knockout mice were generated.

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