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Mice

Rag2/IL2rg-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210231

Exon 3 of Rag2 and exon 2 of IL2rg gene was deleted to generate Rag2 and IL2rg knockout mice.

Mice

hIL3-hCSF2-Tg(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1Tg(hIL3-hCSF2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215006

These transgenic mice carry humanized IL3 and humanized CSF2.

Mice

Ern1-Flox

Strain Name：B6;129S-Ern1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00077

An frt-neo-frt cassette was inserted after exon 2 and loxP sites was inserted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

hFCGRT(NMG）

Strain Name：NOD-PrkdcscidIl2rgem1Fcgrtem2(FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-020

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

Mice

Cdkn2a-Flox(p16/p19-Flox)

Strain Name：C57BL/6Smoc-Cdkn2aem3(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200015

These mice carry loxP sites flanking exon 2 of the common region of Cdkn2a-p19ARF and Cdkn2a-p16INK4a transcripts.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain explicitly states that fluorescence cannot be directly observed.

Mice

ICR

Strain Name：Smoc:ICR
Strain State：Repository Live | Cat. NO.：SM-006

ICR mice have good reproductive performance, strong disease resistance, a gentle temperament, and are generally used for safety evaluation, pharmacological and toxicological research, aging research, surgical experiments, and so on. They are also suitable for surrogate suckling and false pregnancy.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

hCD20(2)

Strain Name：C57BL/6Smoc-Ms4a1tm2 (hCD20)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200114

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.

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