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Mice

Trpv1-IRES-Cre

Strain Name：C57BL/6Smoc-Trpv1em1(Myc-IRES-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200139

A Myc-IRES-Cre expression cassette was knocked into the Trpv1 gene stop codon site. Trpv1 is known as transient receptor potential cation channel, subfamily V, member 1. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying the pain caused by heat and capsaicin.

Mice

Pdyn-IRES-Cre

Strain Name：C57BL/6Smoc-Pdynem1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200089

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.

Mice

Oprk1-2A-Cre

Strain Name：C57BL/6Smoc-Oprk1em1(2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200299

2A-Cre expression cassette was knocked into the Oprk1 gene stop codon site. Oprk1 (opioid receptor, kappa 1) encodes opioid receptor which was expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.

Mice

R26-CAG-LSL-mCherry-EGFP-LC3

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-mCherry-EGFP-Map1lc3a-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00124

The CAG promoter-loxp-stop-loxp-mCherry-EGFP-Map1lc3a-WPRE-polyA expression cassette was inserted into the Rosa26 gene locus by homologous recombination. Map1lc3a, also known as LC3, is a widely expressed autophagic vesicle-specific marker. There was no abnormality in heterozygous mice. The presence of the loxp-stop-loxp expression cassette prevented the transcription of the downstream target gene LC3. After mating with Cre mice, LC3 gene is driven by the CAG promoter to express mCherry and EGFP in a pH-dependent manner in phagocytic cells after ischemic injury in the progeny double positive mice. The two co-expressed fluorescent signals vary depending on the acidic environment of the autophagic vesicles within the cell. mCherry is stable in an acidic environment (pKa 4.5), and quenching occurs in the acidic environment (pKa 5.9) of EGFP in lysosomes. In the autophagy vesicles with higher pH, the fluorescence of GFP and mCherry superimposed on yellow fluorescence; while in the lower pH lysosome, EGFP was quenched and only red fluorescence signal was detected. It can be used to label and track LC3 and study the origin, progression and disappearance of autophagy in various tissues after ischemic injury.

Mice

Slc6a11-CreERT2

Strain Name：C57BL/6Smoc-Slc6a11em1(CreERT2-polyA(SV40)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200130

A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects.

Mice

Bhlha15-CreERT2

Strain Name：C57BL/6Smoc-Bhlha15em1(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200080

The coding region of Bhlha15 gene was replaced by a CreERT2 expression cassette.Besides,a kozak-CreERT2-WPRE-polyA expression cassette were knock into the Bhlha15 gene start codon site to generate Bhlha15-CreERT2(2)(Stock No. NM-KI-200158) mice. Bhlha15(basic helix-loop-helix family member a15) is also known as Mist1. The gene product is involved in controlling exocrine secretion from the pancreas, small intestine and stomach. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Bhlha15.

Mice

SCID

Strain Name：SCID/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-015

SCID mice, also known as Severe Combined Immune Deficient mice, were first discovered in 1983 by Bosma M.J. from the C.B-17/Icr inbred strain of mice. This condition is caused by a mutation in a single recessive gene located on chromosome 16, also referred to as the SCID gene. SCID mice are a congenic strain of C.B-17/lcrJ, with white fur. This strain exhibits severe combined immune deficiency, characterized by the absence of functional B cells and T lymphocytes. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Additionally, the thymus, lymph nodes, and splenic follicles of these mice are virtually devoid of lymphocytes. However, SCID mice possess normal natural killer (NK) cells, macrophages, and granulocytes. SCID mice are commonly used for the transplantation of allogeneic or xenogeneic tissues and are ideal models for cell transplantation experiments.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Cacna1c-KO

Strain Name：C57BL/6Smoc-Cacna1Cem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190926

Exon 3 of Cacna1c gene was deleted to generate Cacna1c knockout mice.

Mice

Tpsb2-KO

Strain Name：C57BL/6Smoc-Tpsb2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190891

Exon 2 of Tpsb2 gene was deleted to generate Tpsb2 knockout mice.

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