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Models

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Mice

Adgra2-Flox

Strain Name：B6;129S-Adgra2tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00101

These Gpr124 flox mutant mice possess loxP sites flanking exon 2 of the G protein-coupled receptor 124 (Gpr124) targeted gene. Homozygotes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

Mice

Myf5-Cre

Strain Name：C57BL/6Smoc-Myf5em1(Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200147

A Cre-WPRE-polyA expression cassette was knocked into the Myf5 gene start codon site. Myogenic factor 5 (Myf5) belongs to the MRF family transcription factors that regulate myogenesis. It is expressed in the skeletal muscle and satellite cells. Severe loss of skeletal muscle following ablation of Myf5-expressing progenitors. This strain is useful in studying the differentiation of skeletal muscle.

Mice

Ntrk2-CreERT2

Strain Name：C57BL/6Smoc-Ntrk2em1(CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200146

A CreERT2-WPRE-polyA expression cassette was knocked into the Ntrk2 gene start codon site. Ntrk2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. When these Ntrk2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Ntrk2 expressing cells.

Mice

R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190010

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

Mice

Slc6a4-Cre

Strain Name：C57BL/6Smoc-Slc6a4em1(iCre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200115

A iCre-pA expression cassette was knocked into the Slc6a4 gene start codon site. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. The gene product has been involved in the neurological disorders such as addiction and depression.

Mice

Trp53-KO

Strain Name：B6.129-Trp53tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00011

A neo cassette replaces exons 2-11,including the start codon,of Trp53 (transformation related protein 53).Null homozygotes show high, early-onset tumor incidence;some have persistent hyaloid vasculature and cataracts.

Mice

BALB/c Nude

Strain Name：BALB/cAnSmoc-Foxn1nu/Smoc
Strain State：Repository Live | Cat. NO.：SM-014

This strain carries a Foxn1nu mutation on the BALB/c background which will lead to T cell deletion. At the same time, the response to thymus-dependent antigens is limited, resulting in impaired B cell function while NK cells, macrophages, and antigen-presenting cells function normally. The complement activity is normal as well. Hair dysplasia causes aberrant hair growth in which the majority of the hair cannot protrude from the surface, resulting in a naked mouse phenotype.

Mice

Crhr1/N-EGFP-Flox

Strain Name：C57BL/6Smoc-Crhr1em1(N-EGFP, flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-2100082

These mice carry loxP sites flanking exon 2 of Crhr1 gene. The EGFP element is inserted into exon 2 of Crhr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crhr1 gene. Construction strategy references Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

Mice

Lepr-g.G109052T

Strain Name：B6.129S-Leprtm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00001

A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.

Mice

Icosl-KO(3)

Strain Name：C57BL/6Smoc-Icoslem3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210308

Icosl-KO(3) mice(Stock No.NM-KO-210308) carry a knockout allele derived from the targeted deletion of exon 2-3. While Icosl-KO mice(Stock No.NM-KO-190721) and Icosl-KO(2) mice(Stock No.NM-KO-200716) carrying the exon 2 deletion.

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